PARP
PARP (Poly (ADP-ribose) polymerase) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or "PARP7"), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair. PARP activation is an immediate cellular response to metabolic, chemical, or radiation-induced DNA SSB damage.
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Rucaparib phosphate是PARP抑制剂，对PARP1的Ki为1.4 nM，对PARP其余亚型也有亲和性。
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PJ34 HCl 是PJ34的盐酸盐形式，是一种PARP抑制剂，EC50为20 nM，同等有效作用于PARP1/2。
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Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂，IC50为5 nM/1 nM，比对Tankyrase-1的抑制作用强300倍。
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Iniparib (BSI-201)是一种PARP1抑制剂，对三阴性乳腺癌(TNBC)有效。
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INO-1001是PARP抑制剂，IC50为3 nM。
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Rucaparib phosphate是PARP抑制剂，对PARP1的Ki为1.4 nM，对PARP其余亚型也有亲和性。
More
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PJ34 HCl 是PJ34的盐酸盐形式，是一种PARP抑制剂，EC50为20 nM，同等有效作用于PARP1/2。
More
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Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂，IC50为5 nM/1 nM，比对Tankyrase-1的抑制作用强300倍。
More
-
Iniparib (BSI-201)是一种PARP1抑制剂，对三阴性乳腺癌(TNBC)有效。
More
-
INO-1001是PARP抑制剂，IC50为3 nM。
More
